Brown Ditch US 421 Bridge (White County, Indiana)
Built 1929; rehabilitated 1960
Concrete arch bridge over Brown Ditch on US 421
Open to traffic

Cape Fear Memorial Bridge (New Hanover County, North Carolina)
Built 1969
Vertical lift bridge over Cape Fear River on US 76/421 in Wilmington
Open to traffic

Clay's Ferry Bridge (Fayette County, Kentucky)
Built 1946 as part of US 25; twin span added 1963 as part of I-75; both spans widened in 1998 to form a single six-lane bridge
Deck truss bridge over the Kentucky River on I-75/US 25/US 421 at Clay's Ferry south of Lexington in Lexington
Open to six lanes of traffic

Clifty Creek Old US 421 Bridge (Decatur County, Indiana)
Built 1935
Concrete arch bridge over Clifty Creek on Old US 421
Open to traffic

Cripe Run US 421 Bridge (Clinton County, Indiana)
Built 1931
Concrete arch bridge over Cripe Run on US 421
Open to traffic

Finley Creek US 421 Bridge (Boone County, Indiana)
Built 1931; rehabilitated 1986
Concrete arch bridge over Finley Creek on US 421
Open to traffic

Hoagland Ditch US 421 Bridge (White County, Indiana)
Built 1929; rehabilitated 1960
Concrete arch bridge over Hoagland Ditch on US 421
Open to traffic

Kilmore Creek US 421 Bridge (Clinton County, Indiana)
Built 1940; rehabilitated 1985
Pony truss bridge over Kilmore Creek on US 421
Open to two-lane traffic

Little Graham Creek US 421 Bridge (Ripley County, Indiana)
Built 1931; rehabilitated 1968
Concrete arch bridge over Little Graham Creek on US 421
Open to traffic

Madison-Milton Bridge (Jefferson County, Indiana)
Built 1928-29; rehabilitated 1997
Cantilevered through truss bridge over Ohio River on US 421 between Madison, IN, and Milton, KY
Open to traffic

Muscatatuck River US 421 Bridge (Decatur County, Indiana)
Built 1929; rehabilitated 1961
Concrete arch bridge over V Fork Muscatatuck River on US 421
Open to traffic

South Fork US 421 Bridge (Clinton County, Indiana)
Built 1940; rehabilitated 1985
Pony truss bridge over South Fork Wildcat Creek on US 421
Open to traffic

Wabash River US 421 Bridge (Carroll County, Indiana)
Replaced 1996
Lost bridge over Wabash River on US 421
Replaced by modern bridge